Mix the first four ingredients and apply rub to brisket. Sear brisket on medium high heat with grapeseed oil till brown on both sides. Put into oven proof Dutch oven with top.
Combine ingredients for miso syrup glaze. Pour wine on brisket as well as miso syrup mix. Cover brisket and braise in 300°F oven for four hours.
Remove from oven (brisket should be very tender). Remove from sauce and set aside. This can be done the day before if desired. Remove fat from sauce and reduce by 1/3.
Heat grill to medium high, cook brisket till warmed throughout, about 10-15 minutes, with lid down. Apply sauce and cook for 3 minutes on each side. Carve and serve remaining sauce on the side.